Cyclopamine - Hedgehog Antagonist. CAS# 4449-51-8 0077 3)14-20(23)28/h9-12

3)14-20(23)28/h9-12

MLN8237 induced polyploidization and expression of mature megakaryocyte markers in acute megakaryocytic leukemia (AMKL) blasts and displayed potent anti-AMKL activity in vivo

selective and cell permeable Jumonji histone demethylase inhibitor

Formula: C30H40ClN7O3S

Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability

Cyclopamine - Hedgehog Antagonist. CAS# 4449-51-8 0077 3)14-20(23)28/h9-12Cyclopamine, CAS No. 4449 51 8, is a potent and selective inhibitor of the hedgehog signaling with an IC50 ~46 nM, acting as an antagonist of Smoothened. It is a natural product isolated from the corn lily (Veratrum californicum). As the hedgehog signaling pathway plays very important roles in embryogenesis and cancer progression, Cyclopamine has been used in stem cell differentiation, such as pancreatic cell differentiation from ESC iPSC, or treating